• Datas

    04 a 07 de novembro de 2025

  • Local

    Natal - RN

  • Submissões até

    31/07/2025

Programação Geral


  • Terça-feira04/11/2025
  • Quarta-feira05/11/2025
  • Quinta-feira06/11/2025
  • Sexta-feira07/11/2025


08:00 - 17:00

Congress accreditation

09:00 - 12:00

Pre-event shortcourse

Shortcourse 1
How to write a scientific article for publication
Speaker
Deborah Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
Shortcourse 2
Brain Organoids: Modeling Neurodegenerative Diseases
Speaker
Natália Chermont dos Santos
UCSD.
Shortcourse 3
Fish Cell lines and OECD 236 simplified: Essential tools for ecotoxicological studies with fish
Speaker
Augusto Monteiro
Z-Safe Biotecnologia LTDA e Departamento de Biologia Celular e Genética - UFRN
Speaker
Francisco Carlos da Silva Júnior
Department: Toxicology Centre - University of Saskatchewan.
14:00 - 17:00

Pre-event shortcourse

Shortcourse 4
Command-line-free transcriptome analysis: using the Galaxy web platform
Speaker
Thais Teixeira Oliveira
Departamento de Biologia Celular e Genética - UFRN.
Speaker
Júlia Firme Freitas
UFRN
Shortcourse 5
Biological assays and experimental procedures for the evaluation of mutagenicity and genotoxicity by chemicals in mammalian cells
Speaker
Elza Tiemi Sakamoto Hojo
FFCLRP-USP
Speaker
Daisy M. Favero Salvadori
UNESP-Botucatu
Speaker
Glenda Nicioli da Silva
UFOP-Ouro Preto
17:00 - 18:00

Opening session

Welcome message - MutaGen-Brazil Board
Tribute to Dr. Sílvia Regina Batistuzzo de Medeiros (UFRN)
Opening lecture
Structure and repair of replication-coupled DNA breaks
Speaker
André Nussenzweig
National Cancer Institute, NIH, Bethesda, USA
Chair
Roger Woodgate
National Institute of Child Health and Human Development, NIH, Rockville, USA
09:00 - 12:00

Get together at beach

Activity 1
Will be a time for socializing and relaxation in a seaside setting. This gathering will allow researchers and students to network, share ideas, and make new friends in a serene environment before the sessions begin. Tables and tents will be set up in front of the event hotel on Ponta Negra beach (Natal), and graduate and postgraduate students will sign up to talk to the guest speakers. In a relaxed atmosphere they will be able to discuss their research projects
Activity 2
Activities aimed at the public and elementary and high school students: a- talk to a scientist; b- distribution of scientific dissemination materials; b- dramatization "The Mutation Trial"; c- storytelling for children and adolescents; d- practical activity of measuring the incidence of UV light.
13:00 - 14:00

Technical conference

To be defined (Exhibiting companies)
14:00 - 15:00

Conferences

Conference A
Human Brain Organogenesis and Applications in Mutagenesis at the International Space Station
Speaker
Alysson Muotri
Department of Pediatrics and Cellular & Molecular Medicine, University of San Diego, San Diego, USA
Chair
Elza Tiemi Sakamoto Hojo
FFCLRP-USP
Conference B
Evaluation of Genotoxicity Biomarkers in Firefighters: Insights from a Portuguese Study and Global Public Health Implications
Speaker
João Paulo Teixeira
Environmental Health Department Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Chair
Vanessa Andrade
UNESC
15:00 - 17:00

Symposia

The relevance of animal models for risk evaluation in mutagenesis and genetic toxicology
Chair
Riva Oliveira
UFRN
Drosophila melanogaster as a model organism for monitoring and analyzing genotoxicity associated with city air pollution
Speaker
Cláudia Rohde
UFPE
Caenorhabditis elegans as a tool for assessing genotoxicity and reprotoxicity of emerging contaminants
Speaker
Maria Fernanda Hornos Carneiro
PUC- Chile
Neurotoxicity-induced by pesticides in Caenorhabditis elegans: are the changes mitigated by nanoformulations?
Speaker
Daiana Silva de Ávila
UNIPAMPA
Freshwater animals as biological models for toxicological studies
Speaker
Cláudia Bueno dos Reis Martinez
UEL
15:00 - 17:00

Symposia: Interplay between DNA repair, chromatin and transcription

Chair
Lucymara Fassarela Agnez Lima
UFRN
Repair of oxidative DNA damage in the chromatin context
Speaker
Anna Campalans
Université Paris-Cité, Paris, France
Genome organization in DNA repair
Speaker
Evi Soutoglou
University of Sussex, Brighton, UK
Understanding the non-repair face of Base Excision Repair: novel perspectives in cancer biology
Speaker
Gianluca Tell
Università di Udine, Udine, Italy
Polymerase II Degradation Triggered by DNA Repair Occurs In Trans and Independently of how the Lesion is
Speaker
Manuel Muñoz
University of Buenos Aires
17:00 - 17:30

Coffee break

17:30 - 19:30

Symposia: Genome Instability in Trypanosomatids

Chair
Carlos Renato Machado
UFMG
A coherent model for the initiation and execution of trypanosome immune evasion through targeted antigen gene recombination?
Speaker
Richard McCulloch
University of Glasgow, Glasgow, Scotland
Epigenetic mechanisms affect gene expression in Trypanosoma cruzi
Speaker
Carlos Robello
Instituto Pasteur, Montevideo, Uruguay
Could a perturbation in the inositol pyrophosphates pathway impair telomere length homeostasis in Leishmania?
Speaker
Marcelo Santos da Silva
IQ-USP
The involvement of the R-loop in the genetic stability of Trypanosoma cruzi
Speaker
Carlos Renato Machado
UFMG
17:30 - 19:30

Symposia

Human biomonitoring for different kinds of exposure to hazardous agents
Chair
Mariana Gobbo Braz
UNESP, Botucatu
Toxicogenetics assays for the detection of exposure to pesticides
Speaker
Juliana da Silva
Unilasalle
Wildfires in Amazon: Assessing the impact and health risks
Speaker
Marcos Felipe de Oliveira Galvão
Karolinska Institute, Stockholm, Sweden
Cytogenetics monitoring following radiation exposure
Speaker
Wilton Takeshita
UNESP
Evaluation of occupational exposure to anesthetic drugs
Speaker
Mariana Gobbo Braz
UNESP, Botucatu
19:30 - 20:30

Poster presentation

09:00 - 12:00

General Assembly of MutaGen-Brasil members

13:00 - 14:00

Technical conference

To be defined (Exhibiting companies)
14:00 - 15:00

Conferences

Conferece A
DNA damage signaling to mitochondria in neurodegeneration and aging
Chair
Nadja Souza Pinto
IQ-USP
Speaker
Vilhelm Bohr
Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
Conferece B
Risk assessment, ecotoxicogenomics and hazard characterization of contaminants in native fishes and amphibians
Chair
Silvia Batistuzzo
UFRN
Speaker
Markus Hecker
School of Environment & Sustainability, University of Saskatchewan, Saskatoon, Canada
15:00 - 17:00

Symposia

From 2D monolayers to 3D models (spheroids/organoids): the next generation of cell culture models applied to toxicogenomics
Chair
Diego Luís Ribeiro
ICB-USP
2D and 3D cultured malignant breast cells as preclinical models for screening anticancer phytochemicals
Speaker
Juliana Mara Serpeloni
UEL
Exploring tumor resistance towards ferroptosis and chemotherapy using 3D models
Speaker
Clarissa Ribeiro Reily Rocha
EPM/UNIFESP
Preclinical evaluation of the activity and toxicity of KRAS inhibitors in 3D Tumor Spheroids
Speaker
Renato José da Silva Oliveira
CPOM/Hospital de Amor de Barretos
Temozolomide Resistance Mechanisms: Unveiling the role of Translesion DNA Polymerases in Glioblastoma 3D Spheroids in vitro
Speaker
Diego Luís Ribeiro
ICB-USP
Selected Young Research Presentation
A definir
15:00 - 17:00

Symposia

Mechanisms of DNA damage signalling and repair in different cellular contexts
Chair
José Renato Cussiol
UNIFESP
Signaling Mechanisms Controlling Genome Maintenance
Speaker
Markus Smolka
Cornell University, Ithaca, USA
Genomic Stress and DNA Repair Mechanisms in the Second Brain
Speaker
David M. Wilson
Hasselt University, Hasselt, Belgium
Stability of the telomerase RNA component is essential for genome integrity and cellular function in the hematopoietic system
Speaker
Luís Batista
Washington University, Saint Louis, USA
Dissecting the mechanisms of horizontal gene transfer in Helicobacter pylori
Speaker
Pablo Radicella
CEA, Paris, France
Selected Young Research Presentation
A definir
17:00 - 17:30

Coffee break

17:30 - 19:30

Symposia

Approaches in Environmental Mutagenesis
Chair
Ana Christina Brasileiro Vidal
UFPE
Deciphering the Impact of Retene, a Neglected Environmental Pollutant, on Human Lung Cells
Speaker
Silvia Batistuzzo
UFRN
Reduction of cytotoxicity and genotoxicity of azo dyes and their by-products by biodegradation processes
Speaker
Ana Christina Brasileiro Vidal
UFPE
Combining metabolomic/multi-omic approaches to identify anticancer and chemopreventive promising drug candidates in food and plants
Speaker
Carlos Fernando Araujo Lima de Oliveira
UNIRIO
Selected Young Research Presentation
A definir
17:30 - 19:30

Symposia

DNA repair and cancer
Chair
Fábio Forti
IQ/USP
Persistent DNA repair intermediates and human DNA repair disease
Speaker
Willem Johannes Lans
Erasmus Medical Center, Rotterdam, Netherlands -
Chromosomal instability: a prelude to cell killing or an avoidable side effect of chemotherapy
Speaker
Vanesa Gottifredi
Instituto Leloir, Buenos Aires, Argentina
Targeting the actin cytoskeleton to challenge genomic integrity in treatment-resistant tumor cells
Speaker
Fábio Forti
IQ/USP
Selected Young Research Presentation
A definir
19:30 - 20:30

Poster presentation

09:00 - 10:00

Conferences

Conference A
PARP activity in DNA replication, repair, and human disease
Chair
Nícolas Hoch
IQ-USP
Speaker
Keith Caldecott
Genome Damage and Stability Centre, University of Sussex, Brighton
Conference B
Epidemiology and Genetics of Internal Tumors in DNA-Repair Deficient Xeroderma Pigmentosum Patients
Chair
Carlos Frederico Martins Menck
ICB-USP
Speaker
Alain Sarasin
Institute Gustave Roussy, Villejuif, France
10:00 - 12:00

Symposia

DNA replication and Mutagenesis
Chair
Rodrigo Galhardo
ICB-USP
Oncogene-induced replication stress and genomic instability in human cancer
Speaker
Leonardo Karam Teixeira
INCA
Regulation of Highly Mutagenic PolVR391 in Enterobacteriaceae
Speaker
Roger Woodgate
National Institute of Child Health and Human Development, NIH, Rockville, USA
New insights into the functions of DNA polymerase zeta in mammalian cells
Speaker
Patricia Kannouche
University Paris-Saclay, Paris, France
Accidental encounters of DNA repair intermediates lead to double-strand breaks in the absence of replication
Speaker
Robert P. Fuchs
BioHalosis SAS Marseille
13:00 - 14:00

Technical conference

To be defined (Exhibiting companies)
14:00 - 16:00

Symposia

Mutagenesis and environmental quality
Chair
Deborah Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
New approach to evaluate chemical hazard and environmental quality for genotoxicity using the tropical marine amphipod, Parhyale hawaiensis
Speaker
Gisela Umbuzeiro
UNICAMP
Bringing genotoxicity closer to the lay population
Speaker
Israel Felzenswalb
UERJ
Understanding the IARC monographs
Speaker
Aline de Conti
InternatioEnnal Agency for Research on Cancer- IARC:
Water quality monitoring and genotoxicity - São Paulo state experience
Speaker
Deborah Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
14:00 - 16:00

Symposia

New molecular approaches in cancer therapy
Chair
Wilner Martínez-López
IIBCE, Montevideo, Uruguay
Exploiting mutagenic processes in cancer for therapeutic benefit
Speaker
Abby Green
Washington University, Saint Louis, USA
Exploring Translesion DNA Polymerases as Therapeutic Targets to Improve Chemotherapy in Glioblastoma
Speaker
Carlos Frederico Martins Menck
ICB-USP
Epigenetic modulation to sensitize cancer cells or protect surrounding healthy tissues under radiotherapy in HPV-associated cancers
Speaker
Wilner Martínez-López
IIBCE, Montevideo, Uruguay
Apresentação Jovem Pesquisador Selecionado
A definir
16:00 - 17:00

Conference

DNA damage and transcription stress and the unexpected impact of nutrition on aging and medicine
Chair
Carlos Frederico Martins Menck
ICB-USP
Speaker
Jan Hoeijmakers
Department of Molecular Genetics, Erasmus Medical Centre, Rotterdam, Netherlands
17:00 - 18:00

Closing ceremony

Closing ceremony and student awards