• Datas

    04 a 07 de novembro de 2025

  • Local

    Natal - RN

  • Submissões até

    08/08/2025

Programação Geral


  • Terça-feira04/11/2025
  • Quarta-feira05/11/2025
  • Quinta-feira06/11/2025
  • Sexta-feira07/11/2025


08:00 - 17:00

Congress accreditation

09:00 - 12:00

Pre-event shortcourse

Shortcourse 1
How to write a scientific article for publication
Speaker
Deborah Arnsdorff Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
Shortcourse 2
Fish Cell lines and OECD 236 simplified: Essential tools for ecotoxicological studies with fish
Speaker
Augusto Monteiro
Z-Safe Biotecnologia LTDA e Departamento de Biologia Celular e Genética - UFRN
Speaker
Francisco Carlos da Silva Júnior
Department: Toxicology Centre - University of Saskatchewan.
14:00 - 17:00

Pre-event shortcourse

Shortcourse 3
Command-line-free transcriptome analysis: using the Galaxy web platform
Speaker
Thais Teixeira Oliveira
Departamento de Biologia Celular e Genética - UFRN.
Speaker
Júlia Firme Freitas
UFRN
Shortcourse 4
Biological assays and experimental procedures for the evaluation of mutagenicity and genotoxicity by chemicals in mammalian cells
Speaker
Elza Tiemi Sakamoto Hojo
FFCLRP-USP
Speaker
Larissa O. Piassi
FMRP-USP
Speaker
Glenda Nicioli da Silva
UFOP-Ouro Preto
17:00 - 18:00

Opening session

Welcome message - MutaGen-Brazil Board
Tribute to Dr. Sílvia Regina Batistuzzo de Medeiros (UFRN)
Opening lecture
Genetics of Internal Tumors in DNA-Repair Deficient Xeroderma Pigmentosum Patients
Speaker
Alain Sarasin
Institute Gustave Roussy, Villejuif, France
Chair
Carlos Frederico Martins Menck
ICB-USP
09:00 - 12:00

Get together at beach

Activity 1
Will be a time for socializing and relaxation in a seaside setting. This gathering will allow researchers and students to network, share ideas, and make new friends in a serene environment before the sessions begin. Tables and tents will be set up in front of the event hotel on Ponta Negra beach (Natal), and graduate and postgraduate students will sign up to talk to the guest speakers. In a relaxed atmosphere they will be able to discuss their research projects
Activity 2
Activities aimed at the public and elementary and high school students: a- talk to a scientist; b- distribution of scientific dissemination materials; b- dramatization "The Mutation Trial"; c- storytelling for children and adolescents; d- practical activity of measuring the incidence of UV light.
13:30 - 14:30

Conferences

Conference 1
Stability of the telomerase RNA component is essential for genome integrity and cellular function in the hematopoietic system.
Speaker
Luís Batista
Washington University, Saint Louis, USA
Chair
Elza Tiemi Sakamoto Hojo
FFCLRP-USP
Conference 2
Evaluation of Genotoxicity Biomarkers in Firefighters: Insights from a Portuguese Study and Global Public Health Implications
Speaker
João Paulo Teixeira
Environmental Health Department Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Chair
Juliana da Silva
Unilasalle
14:30 - 16:30

Symposia 1: Genome Instability in Trypanosomatids

Chair
Carlos Renato Machado
UFMG
A coherent model for the initiation and execution of trypanosome immune evasion through targeted antigen gene recombination?
Speaker
Richard McCulloch
University of Glasgow, Glasgow, Scotland
Epigenetic mechanisms affect gene expression in Trypanosoma cruzi
Speaker
Carlos Robello
Instituto Pasteur, Montevideo, Uruguay
Could a perturbation in the inositol pyrophosphates pathway impair telomere length homeostasis in Leishmania?
Speaker
Marcelo Santos da Silva
IQ-USP
The involvement of the R-loop in the genetic stability of Trypanosoma cruzi
Speaker
Carlos Renato Machado
UFMG
14:30 - 16:30

Symposia 2

Human biomonitoring for different kinds of exposure to hazardous agents
Chair
Mariana Gobbo Braz
UNESP, Botucatu
Toxicogenetics assays for the detection of exposure to pesticides
Speaker
Juliana da Silva
Unilasalle
Wildfires in Amazon: Assessing the impact and health risks
Speaker
Marcos Felipe de Oliveira Galvão
Karolinska Institute, Stockholm, Sweden
Cytogenetics monitoring following radiation exposure
Speaker
Wilton Takeshita
UNESP
Evaluation of occupational exposure to anesthetic drugs
Speaker
Mariana Gobbo Braz
UNESP, Botucatu
16:30 - 17:00

Coffee break

17:00 - 18:30

Symposia 3

The relevance of animal models for risk evaluation in mutagenesis and genetic toxicology
Chair
Riva Oliveira
UFRN
Drosophila melanogaster as a model organism for monitoring and analyzing genotoxicity associated with city air pollution
Speaker
Cláudia Rohde
UFPE
Caenorhabditis elegans as a tool for assessing genotoxicity and reprotoxicity of emerging contaminants
Speaker
Maria Fernanda Hornos Carneiro
PUC- Chile
Freshwater animals as biological models for toxicological studies
Speaker
Cláudia Bueno dos Reis Martinez
UEL
17:00 - 18:30

Symposia 4: Interplay between DNA repair, chromatin and transcription

Chair
Julliane Tamara Araújo de Melo Campos
UFRN
Repair of oxidative DNA damage in the chromatin context
Speaker
Anna Campalans
Université Paris-Cité, Paris, France
Exploiting mutagenic processes in cancer for therapeutic benefit
Speaker
Abby Green
Washington University, Saint Louis, USA
Polymerase II Degradation Triggered by DNA Repair Occurs in Trans and Independently of how the Lesion is Recognized
Speaker
Manuel Muñoz
University of Buenos Aires
18:30 - 19:30

Poster presentation

10:00 - 12:00

General Assembly of MutaGen-Brasil members

13:30 - 14:30

Conferences

Conferece 3
Persistent DNA repair intermediates and human DNA repair disease
Chair
Nadja Souza Pinto
IQ-USP
Speaker
Hannes Lans
Erasmus Medical Center, Rotterdam, Netherlands -
Conferece 4
Risk assessment, ecotoxicogenomics and hazard characterization of contaminants in native fishes and amphibians
Chair
Silvia Batistuzzo
UFRN
Speaker
Markus Hecker
School of Environment & Sustainability, University of Saskatchewan, Saskatoon, Canada
14:30 - 16:30

Symposia 5

In vitro 3D models (spheroids/organoids) applied to cancer therapeutic approaches
Chair
Diego Luís Ribeiro
ICB-USP
2D and 3D cultured malignant breast cells as preclinical models for screening anticancer phytochemicals
Speaker
Juliana Mara Serpeloni
UEL
Exploring tumor resistance towards ferroptosis and chemotherapy using 3D models
Speaker
Clarissa Ribeiro Reily Rocha
EPM/UNIFESP
Preclinical evaluation of the activity and toxicity of KRAS inhibitors in 3D Tumor Spheroids
Speaker
Renato José da Silva Oliveira
CPOM/Hospital de Amor de Barretos
Temozolomide Resistance Mechanisms: Unveiling the role of Translesion DNA Polymerases in Glioblastoma 3D Spheroids in vitro
Speaker
Diego Luís Ribeiro
ICB-USP
14:30 - 16:30

Symposia 6

Mechanisms of DNA damage signalling and repair in different cellular contexts
Chair
José Renato Rosa Cussiol
UNIFESP
Mechanistic link between DNA repair and mitochondrial DNA methylation levels
Speaker
Nadja Souza Pinto
IQ-USP
Dissecting the mechanisms of horizontal gene transfer in Helicobacter pylori
Speaker
Pablo Radicella
CEA, Paris, France
Epigenetic modulation to sensitize cancer cells or protect surrounding healthy tissues under radiotherapy in HPV-associated cancers
Speaker
Wilner Martínez-López
IIBCE, Montevideo, Uruguay
PIK3R3 activates PI3K/AKT signaling contributing to drive esophageal squamous cell carcinoma progression representing a promising therapeutic target
Palestrante
João Victor Roza Cruz
INCA (selected abstract)
16:30 - 17:00

Coffee break

17:00 - 19:00

Symposia

Multiple Approaches in Environmental Mutagenesis
Chair
Ana Christina Brasileiro Vidal
UFPE
Deciphering the Impact of Retene, a Neglected Environmental Pollutant, on Human Lung Cells
Speaker
Silvia Batistuzzo
UFRN
Unveiling the Toxic Potential of Retene in Caenorhabditis elegans: Impacts on Redox Homeostasis and Neuronal Integrity
Speaker
Riva Oliveira
UFRN
Reduction of cytotoxicity and genotoxicity of azo dyes and their by-products by biodegradation processes
Speaker
Ana Christina Brasileiro Vidal
UFPE
Combining metabolomic/multi-omic approaches to identify anticancer and chemopreventive promising drug candidates in food and plants
Speaker
Carlos Fernando Araujo Lima de Oliveira
UNIRIO
17:00 - 19:00

Symposia 8

Targeting different cellular and molecular components in tumors versus human neural models
Chair
Fábio Forti
IQ/USP
Chromosomal instability: a prelude to cell killing or an avoidable side effect of chemotherapy
Speaker
Vanesa Gottifredi
Instituto Leloir, Buenos Aires, Argentina
Targeting the actin cytoskeleton to challenge genomic integrity in treatment-resistant tumor cells
Speaker
Fábio Forti
IQ/USP
Neurotoxic compounds and neuroprotective strategies investigated in human neural models
Speaker
Elza Tiemi Sakamoto Hojo
FFCLRP-USP
Comparative molecular characterization of circulating tumor DNA and matched tumor tissue in colorectal cancer
Speaker
Monyse de Nobrega
McGill University (selected abstract)
19:00 - 20:30

Poster presentation

09:00 - 10:00

Conferences

Conference 5
Impact of Sunlight on Mutagenesis and Skin Tumor Development in Xeroderma Pigmentosum Variant
Chair
Lucymara Fassarela Agnez Lima
UFRN
Speaker
Carlos Frederico Martins Menck
ICB-USP
Conference 6
Signaling Mechanisms Controlling Genome Maintenance
Chair
Nícolas Hoch
IQ-USP
Speaker
Markus Smolka
Cornell University, Ithaca, USA
10:00 - 12:00

Symposia 9

Postgraduate Award (papers selected from submitted abstracts)
Inositol Pyrophosphates in double-strand break signaling and repair in budding yeast
Giovanna Marques Panessa (UNIFESP)
Macroautophagy loss causes TMZ resistance and ferroptosis sensitivity via NRF2 activation
Ana Beatriz da Silva Teixeira (UNIFESP)
Copper(II) complexes containing Schiff bases exhibit enhanced efficacy in 2D and 3D colorectal cancer cells via ROS-mediated DNA damage and apoptosis
Ianka Jacondino Nunes (UFCSPA)
Understanding DNA damage response mechanisms and associated pathway regulation induced by arsenite exposure.
Álvaro Jose Benitez de Leon (UFOP)
Evaluation of the role of HMGA1 in the progression of Esophageal Adenocarcinoma
Maria Luísa Barambo Wagner (INCA)
10:00 - 12:00

Symposia 10

Undergraduate Award (papers selected from submitted abstracts)
XPC deficiency alters the expression of genes involved in ribosome biogenesis and inflammatory responses in fibroblasts under oxidative stress
Daniel Mendonça da Silva (UFRN)
Effect of nucleotide excision repair and R-loops on transcriptional regulation in Trypanosoma cruzi
Lucas Henrique Correia Azevedo (UFMG)
Ferroptosis induction sensitizes NSCLC lines resistant to chemotherapy
Luísa Kawakami Piratello (UNIFESP)
Evaluation of the anticancer potential of two copper(ii) complexes containing bipyridine and phenanthroline in colorectal and breast cancer
Leandro Zanin de Morais (UFCSPA)
Development of lipid nanocarriers functionalized with chitosan for optimization of temozolomide therapy in glioblastoma
Helber Alves Negreiros (IEST)
13:30 - 15:30

Symposia 11

Mutagenesis and environmental quality
Chair
Deborah Arnsdorff Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
New approach to evaluate chemical hazard and environmental quality for genotoxicity using the tropical marine amphipod, Parhyale hawaiensis
Speaker
Gisela Umbuzeiro
UNICAMP
Bringing genotoxicity closer to the lay population
Speaker
Israel Felzenswalb
UERJ
Water quality monitoring and genotoxicity - São Paulo state experience
Speaker
Deborah Arnsdorff Roubicek
Companhia Ambiental do Estado de São Paulo - CETESB
Traffic-related air pollution induces genotoxicity in street vendors: evidence from a local cohort study
Speaker
Boscolli Barbosa Pereira
UFU (selected abstract)
13:30 - 15:30

Symposia 12

DNA repair, Replication stress, and Mutagenesis
Chair
Leonardo Karam Teixeira
INCA
Modulation of DNA Repair Pathways by Chemotherapy in Colorectal Cancer: Implications for Prognosis and Therapy
Speaker
Jenifer Saffi
UFCSPA
Accidental encounters of DNA repair intermediates lead to double-strand breaks in the absence of replication.
Speaker
Robert P. Fuchs
BioHalosis SAS Marseille
Oncogene-induced replication stress and genomic instability in human cancer
Speaker
Leonardo Karam Teixeira
INCA
Xeroderma Pigmentosum with Cockayne syndrome and aldehyde metabolism-deficient human cells show increased formaldehyde sensitivity
Speaker
Orlando Soares Louzada Neto
USP (selected abstract)
15:30 - 16:30

Closing Session

DNA damage and transcription stress and the unexpected impact of nutrition on aging and medicine
Chair
Carlos Frederico Martins Menck
ICB-USP
Speaker
Jan Hoeijmakers
Department of Molecular Genetics, Erasmus Medical Centre, Rotterdam, Netherlands
16:30 - 17:30

Closing ceremony

Closing ceremony and student awards